Gene name:
Trpm2 (Ltrpc2;Trpc7) ;
Protein name:
Transient receptor potential cation channel subfamily M member 2 ;
Alternative:
Transient receptor potential channel 7 (TrpC7) ;Long transient receptor potential channel 2 (LTrpC-2;LTrpC2) ;
Organism:
Mouse (Mus musculus).
General Annotation
Function:
Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Has ADP-ribose pyrophosphatase activity.
Subcellular Location:
Membrane
Multi-pass membrane protein
Protein Attributes:
50:
MESLDRRRTG | SEQEEGFGVQ | SRRATDLGMV | PNLRRSNSSL | CKSRRFLCSF |
100:
SSEKQENLSS | WIPENIKKKE | CVYFVESSKL | SDAGKVVCAC | GYTHEQHLEV |
150:
AIKPHTFQGK | EWDPKKHVQE | MPTDAFGDIV | FTDLSQKVGK | YVRVSQDTPS |
200:
SVIYQLMTQH | WGLDVPNLLI | SVTGGAKNFN | MKLRLKSIFR | RGLVKVAQTT |
250:
GAWIITGGSH | TGVMKQVGEA | VRDFSLSSSC | KEGEVITIGV | ATWGTIHNRE |
300:
GLIHPMGGFP | AEYMLDEEGQ | GNLTCLDSNH | SHFILVDDGT | HGQYGVEIPL |
350:
RTKLEKFISE | QTKERGGVAI | KIPIVCVVLE | GGPGTLHTIY | NAINNGTPCV |
400:
IVEGSGRVAD | VIAQVATLPV | SEITISLIQQ | KLSIFFQEMF | ETFTENQIVE |
450:
WTKKIQDIVR | RRQLLTIFRE | GKDGQQDVDV | AILQALLKAS | RSQDHFGHEN |
500:
WDHQLKLAVA | WNRVDIARSE | IFTDEWQWKP | ADLHPMMTAA | LISNKPEFVR |
550:
LFLENGVRLK | EFVTWDTLLC | LYENLEPSCL | FHSKLQKVLA | EEQRLAYASA |
600:
TPRLHMHHVA | QVLRELLGDS | TQLLYPRPRY | TDRPRLSMTV | PHIKLNVQGV |
650:
SLRSLYKRST | GHVTFTIDPV | RDLLIWAVIQ | NHRELAGIIW | AQSQDCTAAA |
700:
LACSKILKEL | SKEEEDTDSS | EEMLALADEF | EHRAIGVFTE | CYRKDEERAQ |
750:
KLLVRVSEAW | GKTTCLQLAL | EAKDMKFVSH | GGIQAFLTKV | WWGQLCVDNG |
800:
LWRIILCMLA | FPLLFTGFIS | FREKRLQALC | RPARVRAFFN | APVVIFHMNI |
850:
LSYFAFLCLF | AYVLMVDFQP | SPSWCEYLIY | LWLFSLVCEE | TRQYLFYDPD |
900:
GCGLMKMASL | YFSDFWNKLD | VGAILLFIVG | LTCRLIPATL | YPGRIILSLD |
950:
FIMFCLRLMH | IFTISKTLGP | KIIIVKRMMK | DVFFFLFLLA | VWVVSFGVAK |
1000:
QAILIHNESR | VDWIFRGVVY | HSYLTIFGQI | PTYIDGVNFS | MDQCSPNGTD |
1050:
PYKPKCPESD | WTGQAPAFPE | WLTVTLLCLY | LLFANILLLN | LLIAMFNYTF |
1100:
QEVQEHTDQI | WKFQRHDLIE | EYHGRPPAPP | PLILLSHLQL | LIKRIVLKIP |
1150:
AKRHKQLKNK | LEKNEETALL | SWELYLKENY | LQNQQYQQKQ | RPEQKIQDIS |
1200:
EKVDTMVDLL | DMDQVKRSGS | TEQRLASLEE | QVTQVTRALH | WIVTTLKDSG |
1250:
FGSGAGALTL | APQRAFDEPD | AELSIRRKVE | EPGDGYHVSA | RHLLYPNARI |
1300:
MRFPVPNEKV | PWAAEFLIYD | PPFYTAEKDV | ALTDPVGDTA | EPLSKISYNV |
1350:
VDGPTDRRSF | HGVYVVEYGF | PLNPMGRTGL | RGRGSLSWFG | PNHTLQPVVT |
1400:
RWKRNQGGAI | CRKSVRKMLE | VLVMKLPRSE | HWALPGGSRE | PGEMLPRKLK |
1450:
RVLRQEFWVA | FETLLMQGTE | VYKGYVDDPR | NTDNAWIETV | AVSIHFQDQN |
1500:
DMELKRLEEN | LHTHDPKELT | RDLKLSTEWQ | VVDRRIPLYA | NHKTILQKVA |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Mouse Transient receptor potential cation channel subfamily M member 2
ELISA Kit for Mouse Transient receptor potential cation channel subfamily M member 2
CLIA Kit for Mouse Transient receptor potential cation channel subfamily M member 2
CLIA Kit for Mouse Transient receptor potential cation channel subfamily M member 2
Polyclonal Antibody for Mouse Transient receptor potential cation channel subfamily M member 2
Polyclonal Antibody for Mouse Transient receptor potential cation channel subfamily M member 2
Monoclonal Antibody for Mouse Transient receptor potential cation channel subfamily M member 2
Monoclonal Antibody for Mouse Transient receptor potential cation channel subfamily M member 2
Protein for Mouse Transient receptor potential cation channel subfamily M member 2
Protein for Mouse Transient receptor potential cation channel subfamily M member 2
R&D Technical Data
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Precision
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Recovery
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Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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References
1.
Kashuba V.
Submitted (2001-08) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
BALB/c .
2.
"LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death."
Hara Y.
,
Wakamori M.
,
Ishii M.
,
Maeno E.
,
Nishida M.
,
Yoshida T.
,
Yamada H.
,
Shimizu S.
,
Mori E.
,
Kudoh J.
,
Shimizu N.
,
Kurose H.
,
Okada Y.
,
Imoto K.
,
Mori Y.
Mol. Cell9:163-173(2002)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY